The Book of Mormon begins with Lehi and his family leaving Jerusalem, making their way through the desert, crossing the sea, and eventually arriving somewhere in the Americas. Among those who are familiar with this narrative, there are some that have assumed the continent was uninhabited at their arrival. If this were true, then all Native Americans should be descendants from Book of Mormon peoples. However, is this an accurate assumption? A closer reading of the scriptures and recent scientific discoveries have shown that this interpretation could be too narrow. Genetic studies have been able to successfully describe broad population trends, and DNA collected from Native Americans revealed their origins in ancient Asia. These results do not necessarily mean that Lehi and his family never existed but only that whatever small genetic contribution they made to the whole indigenous population of the Americas has not been, or cannot be, identified by modern science. A DNA approach cannot prove or disprove the historical authenticity of the Book of Mormon or address the genetics of those who traveled with Lehi to the “promised land.”1 Those who declare otherwise disregard the complexities and constraints of DNA research in population studies.