Abstract: The Book of Mormon claims to be an ancient record containing a summary of a now-disappeared civilization that once lived in the American continent but originated in the Middle East. DNA studies focusing on the ancient migration of world populations support a North-East Asian origin of modern Native American populations arriving through the now-submerged land-bridge that once connected Siberia to Alaska during the last Ice Age, approximately 15,000 years ago. The apparent discrepancy between the Book of Mormon narrative and the published genetic data must be addressed in lieu of generally accepted population genetic principles that are efficient in large-scale population studies, but are somewhat weak and limitative in detecting genetic signals from the introgression of DNA by small groups of outsiders into a large, and well-established population. Therefore, while DNA can definitely provide clues about the ancient history of a people or civilization, it fails to provide conclusive proofs to support or dismiss the Book of Mormon as a true historical narrative.