The field of genetics is in a constant state of flux as it goes about sequencing and interpreting DNA data, continuing to gain additional insights from larger and more robust sampling groups and methods. One of the most exciting things for members of The Church of Jesus Christ of Latter-day Saints is that these findings may provide additional validation for the historical claims of the Book of Mormon and also potentially lend supporting evidence in favor of Joseph Smith's understanding and revelations involving the geography that is outlined within the prophecies and promises of the Book of Mormon.

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A series of specific mtDNA markers distinguishing haplogroup X from other European lineages and its existence in ancient Native North American populations was verified by DNA sequencing. This lineage and other ancient remains have confirmed that haplogroup X was among the ancient American inhabitants of North America. To date, this haplogroup X is the only European lineage known to be a founding or primary genetic contributor to Native American populations throughout the Western Hemisphere. This genetic lineage provides at least a possibility of supporting the claims of Book of Mormon history, the "remnant," and the statements of Joseph Smith.

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Haplogroup X was found at highest frequencies among Native American Algonquian-speaking language groups. These include such tribes as the Arapaho, Blackfoot, Cheyenne, Cree, Gros Ventre, Illini, Kickapoo, Lenni Lenape, Delaware, Lumbee, Mohican, Menominee, Sac and Fox, Miami, Micmac, Ojibwa, Shawnee, Sioux, Wiyot, and Yurok along with many others. This language group today consists of more than 100 individual tribes. Haplogroup X has also been found to be geographically widespread throughout nearly all of North America among groups that share no close historic or linguistic ties, indicating an expansion and subsequent diffusion from the Great Lakes region.

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Haplogroup X, which is the only founding European lineage known to have occurred anywhere in the Americas anciently is found only in the Native American populations in North America. Because of this, haplogroup X is the most likely, and most qualified or suitable candidate lineage for establishing a possible, plausible, and probable case for the historicity of the Book of Mormon.