In this large prospective cohort study of 66,444 married U.S. nurses with 14 years of follow up from mid to late life, and repeated measurements of service attendance to allow for control of prior service attendance, nurses who attended religious service more than once per week had a 50% lower likelihood of subsequent divorce or separation, compared to those who never attend. Among widowed nurses, those who attended services more than once per week had a 49% higher likelihood of remarriage, compared to those who never attended services. However, for divorced or separated -nurses, religious service attendance was not significantly associated with the likelihood of remarriage. We found the associations between religious service attendance divorce, and remarriage were stronger for Catholics than Protestants.